Carlos Portocarrero-Sanchez, David Barreira Gomes-Sobrinho, Hitomi Miura Nakagawa, Adelino Amaral Silva, Bruno Ramalho de Carvalho, Nathália Travassos Sarkis, José Carlos Peraçoli and Maria Teresinha de Oliveira Cardoso


Anovulatory infertility, clomiphene citrate, follicular size, PCOS, pregnancy rate

Objective: To investigate the follicular size at spontaneous rupture on pregnancy rate in patients with polycystic ovary syndrome (PCOS) undergoing clomiphene citrate (CC) ovulation.

Design: Cross-sectional study.

Patients and methods: One hundred and four women with ovulatory cycles after use of CC followed by ultrasound to determine the follicle size at the time of rupture, which was subsequently correlated with the occurrence of pregnancy or not in coit  cycles.

Results: In the group of follicular rupture at a mean diameter 25mm (n¼54), pregnancy rate was 35.1% and when follicular rupture occurred at a mean diameter425mm (n¼50), it was 34% (p40.05). When different diameters at follicular rupture were  randomly correlated with the pregnancy rate, there was no significant difference.

Conclusion: Our data suggest that the occurrence of pregnancy after ovulation induction with CC in women with PCOS is not associated with follicle size at the time of rupture.

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